POLYNUCLEOTIDES FOR HAIR LOSS: A REGENERATIVE SOLUTION
By Shetha Naji, Consultant Plastic Surgeon – October 6, 2025
Hair loss is a deeply personal concern that can affect anyone - both men and women - at any stage of life. It’s also incredibly common: around 50% of women experience noticeable thinning by age 50, while up to 80% of men develop male pattern baldness in their lifetime.
While common, hair loss can feel devastating, often affecting self-confidence and quality of life. Traditional treatments like hair transplants may not be suitable or accessible for everyone. That’s why many people are turning to non-surgical, regenerative solutions.
One of the most exciting innovations in this space is polynucleotide therapy for hair loss - a treatment that uses the body’s own repair mechanisms to encourage healthy, natural hair growth.
WHAT ARE POLYNUCLEOTIDES?
Polynucleotides are natural molecules derived from nucleotides—the building blocks of DNA. They help stimulate cellular repair, regeneration, and hydration, making them a powerful tool in aesthetic medicine.
They have traditionally been used in skin rejuvenation, but growing evidence now supports their effectiveness in hair restoration, thanks to their ability to:
• Boost collagen and fibroblast activity.
• Reduce inflammation.
• Support healthier, stronger hair follicles.
• Improve scalp health.
HOW DO POLYNUCLEOTIDES TREAT HAIR LOSS?
Polynucleotides are injected directly into the scalp, where they stimulate a cascade of regenerative processes:
• Hair Follicle Stimulation – Awakens dormant follicles and encourages growth.
• Improved Circulation – Enhances blood flow, delivering oxygen and nutrients to follicles.
• Inflammation Reduction – Calms irritated scalps, especially in cases like hormonal or stress-related hair loss.
• Stronger Scalp Structure – By stimulating collagen and fibroblasts, they create a healthier environment for hair growth.
This multi-layered approach supports thicker, denser, and healthier hair over time.
THE SCIENCE BEHIND IT
Polynucleotides work by:
1. Stimulating hair follicles to enter the growth (anagen) phase.
2. Encouraging cellular repair for stronger, more resilient hair.
3. Increasing fibroblast activity to boost collagen and support scalp structure.
4. Improving blood vessel formation (angiogenesis), delivering more oxygen andnutrients.
5. Enhancing scalp health overall, reducing inflammation and restoring hydration.
WHAT TO EXPECT FROM TREATMENT
1. Consultation – Your journey begins with a detailed assessment of your scalp and hair loss pattern to ensure this treatment is right for you. Not everyone with hair thinning/loss is suitable and that is why an accurate and thorough assessment is crutial.
2. Procedure – Polynucleotides are injected into thinning areas of the scalp following local anaesthetic. The session typically takes 15-30 minutes.
3. Comfort – The treatment is minimally invasive with small blebs (bumps) evident at the injection sites. Some redness or mild swelling may occur but usually resolves within a few days.
4. Treatment Plan – A typical course involves 3–6 sessions spaced 2–3 weeks apart, followed by a maintenance programme. It is crucial to remember that due to the hair follicle life cycle, all regenerative methods require regular maintenance.
GRADUAL, NATURAL RESULTS
Unlike transplants or instant-thickening products, results build gradually as your scalp regenerates:
• Improved hydration and scalp health.
• Less shedding and breakage.
• Thicker, stronger strands.
• Fuller, denser hair growth over time.
WHO IS IT FOR?
Polynucleotide therapy can benefit both men and women experiencing:
• Early-stage thinning or pattern hair loss.
• Postpartum hair loss.
• Hormonal hair loss (e.g., PCOS or thyroid-related).
• Stress or inflammation-related hair loss.
• Sensitive scalps or those preferring a non-blood-based alternative to PRP.
IMPORTANT NOTE: Polynucleotides cannot regrow hair on areas of complete baldness - there must be some active follicles present.
RESULTS AND MAINTENANCE
Most patients notice early improvements in 6–8 weeks, with results building over time. To maintain long-term benefits, regular maintenance sessions are recommended. Polynucleotides can also complement other hair restoration treatments for even better outcomes. Like most things, a holistic approach is always best.
CHOOSING THE BEST HAIR LOSS TREATMENT
Every person’s hair loss journey is unique. A full medical consultation with me will help determine the underlying cause, assess suitability for polynucleotides, and explore all available treatment options.
I always encourage patients to take their time, ask questions, and feel fully informed before choosing the right path forward.
CONCLUSION: REGENERATING CONFIDENCE
Polynucleotide hair loss treatments are a promising, non-surgical way to:
• Stimulate dormant follicles.
• Improve scalp health.
• Promote natural, gradual, and lasting hair growth.
Whether you’re noticing the first signs of thinning or looking for a gentle, regenerative alternative to surgery, polynucleotides could be the solution you’ve been waiting for.
Tel: +44 (0) 7903 159640
Email: contact@shethanaji.com
Take the first step towards healthier, fuller, and stronger hair today.