POLYNUCLEOTIDE SKIN TREATMENT: WHY IT’S ONE OF MY FAVOURITE REGENERATIVE THERAPIES
By Shetha Naji, Consultant Plastic Surgeon – August 19, 2025
As a Consultant Plastic Surgeon, I’ve explored countless treatments in aesthetic and regenerative medicine. Few excite me as much as polynucleotides for skin rejuvenation. Unlike traditional fillers that simply add volume, polynucleotides actually regenerate your skin from within — working on a cellular level to restore health, elasticity, and radiance.
I love them because they harness your body’s own natural repair mechanisms. The result? Healthier, younger-looking skin that feels revitalised, not artificially enhanced.
In this article, I’ll walk you through what polynucleotides are, how they work, their benefits, and why they might be the perfect solution for you.
WHAT ARE POLYNUCLEOTIDES?
Polynucleotides are DNA fragments (chains of nucleotides — the building blocks of life) used in regenerative medicine. In skin treatments, they stimulate tissue repair, collagen production, and hydration — improving the skin’s structure and appearance at a cellular level.
Unlike dermal fillers, which temporarily add volume, polynucleotides improve the quality of your skin itself. Think of them as a reset button that helps your skin function like it did years earlier.
HOW DO POLYNUCLEOTIDES WORK?
Polynucleotides act as powerful skin healers by:
1. Stimulating tissue regeneration – They encourage fibroblasts (collagen-producing cells) to multiply, boosting collagen and elastin for firmer, smoother skin.
2. Calming inflammation – Their natural anti-inflammatory properties reduce redness, irritation and swelling.
3. Restoring hydration – Polynucleotides bind water molecules, deeply hydrating the skin for a plumper, healthier look.
4. Protecting against oxidative stress – Their antioxidant effects defend against ageing triggers like pollution and UV damage.
BENEFITS OF POLYNUCLEOTIDE SKIN TREATMENT
Patients choose polynucleotides because they deliver results beyond traditional non-surgical
options. Benefits include:
• Improved skin elasticity – restoring firmness and resilience.
• Reduction of fine lines & wrinkles – smoothing the skin naturally.
• Refined texture – reducing acne scars, enlarged pores, and rough patches.
• Improved skin tone and even complexion – increasing radiance, reducing skin colour irregularities and brightening the area, particularly the dark circles we often have under our eyes.
• Deep hydration – long-lasting moisture for a radiant glow.
• Minimal downtime – a non-invasive treatment with quick recovery.
THE SCIENCE BEHIND POLYNUCLEOTIDES
Polynucleotides are often derived from natural sources such as salmon trout DNA, which is highly compatible with human skin. When injected, they trigger your body’s own repair mechanisms to regenerate tissue, boost hydration, and improve overall skin health through
the process of biostimulation.
This science-backed approach explains why they are considered one of the most advanced regenerative therapies in aesthetic medicine today.
WHO CAN BENEFIT FROM POLYNUCLEOTIDES?
Polynucleotide treatments are suitable for a wide range of individuals, including those who want to:
• Address signs of ageing – smooth wrinkles, fine lines, and sagging skin.
• Improve scars & texture – soften acne scars or rough patches.
• Prevent skin ageing – keep skin youthful before visible changes appear.
• Improve appearance of skin – improve skin health and quality, radiance and complexion
WHAT TO EXPECT DURING TREATMENT
1. Consultation – We’ll begin with a personalised consultation, where I assess your skin concerns and create a tailored plan.
2. Procedure – Using fine needles, polynucleotides are injected into the target areas. Prior to any injection, local anaesthetic is used to ensure the treatment is comfortable.
3. Aftercare – Mild redness or swelling may occur but usually subsides quickly. You will receive full aftercare guidance to ensure optimal results.
4. Results – Improvements develop gradually. Most patients notice fresher, smoother skin within weeks, with full results unfolding over several months.
WHY CHOOSE ME FOR YOUR POLYNUCLEOTIDE TREATMENT?
I am deeply passionate about regenerative medicine and have seen first-hand the incredible difference polynucleotides can make. Here’s why patients trust me:
• Expert medical background – As a Consultant Plastic Surgeon with over 18 years’ experience, I combine advanced training with meticulous attention to detail.
• Personalised care – Every patient’s skin is unique. I design treatment plans tailored specifically to your needs and goals.
• Commitment to excellence – I continually update my practice with the latest research and techniques to ensure the highest standard of care.
FAQS ABOUT POLYNUCLEOTIDES
Are polynucleotides safe?
Yes. They are biocompatible, safe, and widely used in medical aesthetics with an excellent safety profile.
How many sessions will I need?
Most patients achieve optimal results with a course of 2–4 treatments, spaced a few weeks apart.
How long do results last?
Results can last up to 12 months, depending on your skin and lifestyle. Maintenance sessions can extend benefits further.
Can polynucleotides be combined with other treatments?
Absolutely — they can complement virtually all aesthetic procedures for enhanced results.
CONCLUSION
Polynucleotides are more than just another non-surgical treatment — they’re the future of skin rejuvenation. By working with your body’s own healing processes, they restore skin health, improve texture, and bring back a natural youthful glow.
If you’re considering polynucleotide treatment for skin rejuvenation, I’d love to guide you on this journey.
Tel: +44 (0) 7903 159640
Email: contact@shethanaji.com
Take the first step towards healthier, more radiant skin today.